Program

Program Proposal in the 10^th International Conference on Legionella 2022

Time Table　 Poster Session

＊Please note: presentation time includes Q&A time (2 to 3 mins).

Opening remarks (September 20, JST 12:40-13:00)

Keynote Lecture 1 (September 20, JST 13:00-13:30)

Chair:

Chikara Nakahama (Nakahama Clinic, Japan)

Speaker:

Paul H. Edelstein (University of Pennsylvania, USA)

Title:

Legionnaires' Disease History

Clinical, Diagnostics and Infection Control and Prevention
Clinical 1: (September 20, JST 13:40-15:10)

Diagnostics and Typing

Chair:

Katsunori Yanagihara (Nagasaki University, Japan)
Yu Chen (Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University)

13:40-14:00

Speaker:

Diane Lindsay (Glasgow Royal Infirmary, UK)

Title:

The hunt to find Legionella species – is PCR the answer?

14:00-14:20

Speaker:

Jacob Moran-Gilad (Ben Gurion University of the Negev, Israel)

Title:

Culture-independent detection of Lp-PCR to metagenomics

14:20-14:40

Speaker:

Kenji Ota (Nagasaki University, Japan)

Title:

Clinical diagnosis of Legionnaires' disease

From general abstracts
14:40-14:50
(id047)

Speaker:

Camille Allam (Centre National de Référence des Légionelles, Hospices Civils de Lyon, France)

Title:

Legionella lung and serum DNA and serum LPS as Legionnaires' disease severity prognosis biomarkers

14:50-15:00
(id022)

Speaker:

Sebastien P. Faucher (Department of Natural Resource Sciences, McGill University, Sainte-Anne-de-Bellevue, Quebec, Canada)

Title:

Searching for the missing strain causing multiyear community-acquired cases of Legionnaires' Disease

Epidemiology and Prevention
Epidemiology and Prevention 1: (September 20, JST 15:20-16:50)

Global trends in Legionnaires' disease

Chair:

Fumiaki Kura (National Institute of Infectious Diseases, Tokyo, Japan)
Jacob Moran-Gilad (Ben Gurion University of the Negev, Beer Sheva, Israel)

15:20-15:40

Speaker:

Yuzo Arima (National Institute of Infectious Diseases, Japan)

Title:

Legionella in Japan: recent trends and distributions based on national surveillance data

15:40-16:00

Speaker:

Lara Payne Hallstrom (European Centre for Disease Prevention and Control)

Title:

Increasing rate of Legionnaires' disease in EU/EEA

16:00-16:20

Speaker:

Albert E. Barskey (CDC/DDID/NCIRD/DBD)

Title:

Increasing Incidence of Legionnaires' Disease in the United States, 1992–2019

From general abstracts:
16:20-16:30
(id006)

Speaker:

Jamie Gorzynski (University of Edinburgh, Roslin Institute)

Title:

Genomic epidemiological analysis of Legionnaires' Disease cases over 36 years in Scotland

16:30-16:40
(id059)

Speaker:

Christophe GINEVRA (Hospices Civils de Lyon, Groupement Hospitalier Nord, Institut des Agents Infectieux, Centre National de Référence des Légionelles, Lyon, France)

Title:

Amplicon-based next-generation sequencing revealed co-infections by several Legionella species

Epidemiology and Prevention 2: (September 20, JST 17:00-18:30)

Preventive and control strategies I

Chair:

Toshiro Kuroki (Okayama University of Science, Japan)
Valeria Gaia (Swiss National Reference Centre for Legionella, Switzerland)

17:00-17:20

Speaker:

Tian Qin (Chinese Centre for Disease Control and Prevention, China)

Title:

Epidemiology of Legionellosis and genetic characterization of Legionella pneumophila in China

17:20-17:40

Speaker:

Itaru Nakamura (Tokyo Medical University, Japan)

Title:

A pragmatic water safety plan for Legionella pneumophilia in a university hospital, Japan

From general abstracts
17:40-17:50
(id057)

Speaker:

Christophe Ginevra (Hospices Civils de Lyon, Groupement Hospitalier Nord, Institut des Agents Infectieux, Centre National de Référence des Légionelles, Lyon, France)

Title:

Sequential culture of respiratory samples highlighted a triple infection by Legionella pneumophila

17:50-18:00
(id094)

Speaker:

Cyrus Ghaznavi (Department of Health Policy and Management, Keio University School of Medicine)

Title:

Effect of State of Emergency Declarations on the Relative Incidence of Legionellosis in Japan

18:00-18:10
(id063)

Speaker:

Emmanuel Robesyn (Karolinska Institutet (KI), Sweden)

Title:

Find, and you shall see how you sought - On Legionnaires' disease surveillance and testing intensity

18:10-18:20
(id061)

Speaker:

Daniel Mäusezahl (Department of Epidemiology & Public Health, Swiss Tropical and Public Health Institute, Allschwil, Switzerland)

Title:

SwissLEGIO –A national case-control and molecular source attribution study on Legionnaires’ disease

Pathogenesis, Immunology, Host interaction, Genetics and Genomics
Pathogenesis 1: (September 21, JST 8:50-10:35)

Pathogenesis, Immunology, Host Interaction I

Chair:

Dario Zamboni (University of Sao Paulo, Brazil)
Zhao-Qing Luo (Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA)

8:50-9:15

Speaker:

Elizabeth Hartland (Monash University, Australia)

Title:

Legionella targeting of host mRNA

9:15-9:40

Speaker:

Michael Steinert (University of Braunschweig, Germany)

Title:

Legionella pneumophila pathogenicity and immune evasion in human lung tissue explants

9:40-10:05

Speaker:

Yousef Abu Kwaik (University of Louisville, USA)

Title:

Paradoxical Macrophages and Neutrophils Responses to an Amoeba Host-Adapted Effector of Legionella pneumophila

From general abstracts
10:05-10:20
(id026)

Speaker:

Tomoko Kubori (Department of Microbiology, Graduate School of Medicine, Gifu University)

Title:

Reversible modification of mitochondrial ADP/ATP translocases by paired Legionella effector proteins

10:20-10:35
(id081)

Speaker:

Pedro Escoll (Institut Pasteur, Biologie des Bactéries Intracellulaires and CNRS UMR 3525, Paris, France)

Title:

L. pneumophila induces the mitochondrial ATPase 'reverse mode' to preserve its replication niche

Pathogenesis 2: (September 21, JST 10:45-12:05)

Pathogenesis, Immunology, Host Interaction II

Chair:

Kohei Arasaki (Tokyo University of Pharmacy and Life Sciences, Japan)
Craig Roy (Yale University School of Medicine, USA)

10:45-11:10

Speaker:

Dario Zamboni (University of Sao Paulo)

Title:

Innate Immune mechanisms involved in the restriction of Legionella replication in mammalian lungs

11:10-11:35

Speaker:

Shaeri Mukherjee (University of California San Francisco, USA)

Title:

A Legionella toxin mimics tRNA and glycosylates the translation machinery

From general abstracts
11:35-11:50
(id015)

Speaker:

Simone Vormittag (Institute of Medical Microbiology, University of Zurich, Switzerland)

Title:

The Legionella-driven Ptdlns(4)P gradient at LCV-ER MCS promotes pathogen vacuole remodeling

11:50-12:05
(id077)

Speaker:

Tomoe Kitao (Department of Microbiology, Graduate School of Medicine, Gifu University)

Title:

Legionella manipulates non-canonical SNARE pairing using post-translational modifications

Lunch Seminar 1 (EIKEN CHEMICAL CO., LTD.)
(September 21, JST 12:15-13:05)

Chair:

Katsunori Yanagihara (Nagasaki University, Japan)

Speaker:

Hideki Araoka (Department of Infectious Diseases, Toranomon hospital, Tokyo, Japan)

Title:

Legionella infections in patients with hematological malignancies

Keynote Lecture 2 (September 21, JST 13:15-14:00)

Chair:

Kazuhiro Tateda (Toho University, Japan)

Speaker:

Toru Miyazaki (The Institute for AIM Medicine, Japan)

Title:

A novel paradigm for disease therapy based on the self-pathogen removal system by apoptosis inhibitor of macrophage (AIM)

Nation-wide clinical research on Legionellosis in Japan
(September 21, JST 14:10-15:10)

Chair:

Kazuyoshi Kawakami (Tohoku University, Japan)

14:10-14:40

Speaker:

Takeshi Kinjo (Ryukyu University, Japan)

Title:

National survey of physicians in Japan to understand the current situation and issues of diagnosing legionellosis

14:40-15:10

Speaker:

Kosaku Komiya (Oita University, Japan)

Title:

Nationwide prospective study on the differences among the Legionella serogroups in Japan

Sponsored Symposium 1 (IDEXX LABORATORIES, INC.)
(September 21, JST 15:30-16:20)

Chair:

Kristin Majeska (IDEXX LABORATORIES, INC.)

Speaker:

MICHÈLE PRÉVOST (Polytechnique Montréal, France)

Title:

Method comparison for the detection of Legionella

Speaker:

Maria Luisa Ricci (Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy/ESCMID Study Group for Legionella Infections (ESGLI), Basel, Switzerland)

Title:

Comparative Quantitative Evaluation of Legiolert* / Quanti-Tray*- Legiolert and the ISO 11731:2017 Method for the Enumeration of Legionella pneumophila in Drinking Water Samples in Italy

Speaker:

Yusuke Yodotani (Kawasaki City Institute for Public Health, Japan)

Title:

Comparative Study between Legiolert/Quanti-Tray and Plate Culture Methods for Detecting L. pneumophila

Speaker:

Sébastien P. Faucher (McGill University, Canada)

Title:

Legiolert for detection and storage of various Legionella pneumophila subspecies

Speaker:

Hiroaki Inoue (AQUAS CORPORATION, Japan)

Title:

Consideration of the difference in results of PCR and plate culture method for detecting Legionella

Sponsored Symposium 2 (IDEXX LABORATORIES, INC.)
(September 21, JST 16:30-17:20)

This panel discussion brings together five experts from three continents for a discussion of the latest scientific data and developments related to rapid-culture, PCR and traditional culture methods.
The panel will consider approaches and criteria for selecting a method and the benefits and trade-offs of employing the different methods for routine testing to reduce Legionnaires' disease risk associated with built environments.

Poster Session
(September 21, JST 17:30-18:30)

Legionella ecology and environment
Ecology 1: (September 22, JST 8:50-10:20)

Chair:

Hubert Hilbi (University of Zürich, Switzerland)
So Fujiyoshi (Hiroshima University, Japan)

8:50-9:15

Speaker:

Nicholas Cianciotto (Northwestern University Medical School, USA)

Title:

Novel role of Legionella pneumophila CRISPR Cas2 in promoting heat tolerance and amoebal infection

9:15-9:40

Speaker:

Stephen Chambers (University of Otago, New Zealand)

Title:

Legionella longbeachae; environmental reservoirs and amplifiers.

From general abstracts
9:40-9:50
(id065)

Speaker:

Torahiko Okubo

Title:

Interaction between Legionella pneumophila and ciliate Anteglaucoma, which is killed by co-culturing

9:50-10:00
(id039)

Speaker:

Kenta Watanabe

Title:

Analysis of the various relationships between Legionella and Paramecium hosts

10:00-10:10
(id024)

Speaker:

Sarah Michaelis

Title:

Nitric oxide signaling regulates the expression of transmissive traits in L. pneumophila

Ecology 2: (September 22, JST 10:30-12:00)

Chair:

Yousef Abu Kwaik (University of Louisville, USA)
Hiroyuki Yamaguchi (Hokkaido University, Japan)

10:30-10:55

Speaker:

Lionel Guy (Uppsala University, Sweden)

Title:

Global diversity and abundance of Legionella(les)

10:55-11:20

Speaker:

Hubert Hilbi (University of Zürich, Switzerland)

Title:

How to kill an environmental phagocyte–Recent insights on Legionella-Dictyostelium interactions

From general abstracts
11:20-11:30
(id013)

Speaker:

Jun-ichi Kanatani

Title:

Characterization of bacterial microbiome in water from public bath, especially focused on Legionella

11:30-11:40
(id012)

Speaker:

Margot Cazals

Title:

Compromised thermal inactivation of L. pneumophila in water heaters in presence of V. vermiformis

11:40-11:50
(id045)

Speaker:

Shira Ninio

Title:

Molecular ecology of Legionella in saline environments

11:50-12:00
(id071)

Speaker:

Kinya Shimmichi (NPO Bathing Sanitation Management-promotion Association)

Title:

Biofilm Formation in Bathing Facilities at Hot Springs –Cleaning Methods and Countermeasures

Lunch Seminar 2 (Abbott Diagnostics Medical Co., Ltd.)
(September 22, JST 12:10-13:00)

Chair:

Hiroki Nagai (Department of Microbiology, Graduate School of Medicine, Gifu University, Japan)

Speaker:

Makoto Ishii (Division of Respiratory Medicine, Nagoya University Graduate School of Medicine, Japan)

Title:

Legionnaires' Disease: Overview and Recent Topics

Sponsored Symposium 3 (KYOKUTO PHARMACEUTICAL INDUSTRIAL CO., LTD.) (September 22, JST 13:10-14:00)

Chair:

Hiroyuki Yamaguchi (Microbiology at the Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Japan)

Speaker:

Yoshihiro Yamamoto (Department of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan)

Title:

Epidemiology and Diagnosis of Legionnaires' Disease in Japan

Keynote Lecture 3 (September 22, JST 14:10-14:40)

Chair:

Hiroyuki Yamaguchi (Hokkaido University, Japan)

Speaker:

Nicholas Ashbolt (Southern Cross University, Australia)

Title:

Role of extracellular vesicles in Legionella–amoebae ecology within engineered water systems

Clinical 2: (September 22, JST 14:50-16:20)

Treatment for Legionella pneumonia

Chair:

Makoto Ishii (University of Nagoya, Japan)
Paul H. Edelstein (University of Pennsylvania, USA)

14:50-15:10

Speaker:

Yu Chen (China Medical University, China)

Title:

Corticosteroid treatment of Legionella pneumonia

15:10-15:30

Speaker:

Sophie Jarraud (National Reference Centre of Legionella, France)

Title:

Towards new immunotherapy strategies for the treatment of severe Legionnaires' disease?

15:30-15:50

Speaker:

Heimo Lagler (Medical University Vienna, Austria)

Title:

Short-term therapy options for Legionnaires' disease

From general abstracts
15:50-16:00
(id098)

Speaker:

Maria Scaturro (Department of Infectious Diseases, Istituto Superiore di Sanità, Rome)

Title:

Antimicrobial susceptibility test of L. pneumophila human strains isolated in Italy (1987-2018)

16:00-16:10
(id051)

Speaker:

Christophe Ginevra (Hospices Civils de Lyon, Groupement Hospitalier Nord, Institut des Agents Infectieux, Centre National de Référence des Légionelles, Lyon, France)

Title:

Legionella pneumophila macrolide resistance: from myth to reality Hospices

Epidemiology and Prevention 3: (September 22, JST 16:30-18:00)

Preventive and control strategies II

Chair:

Dai Shimazaki (National Institute of Public Health, Japan)　
Diane Lindsay (Glasgow Royal Infirmary, UK)

16:30-16:50

Speaker:

Jimmy Walker (UK)

Title:

Thinking outside the box – taking a multidisciplinary approach to Legionella prevention and control

16:50-17:10

Speaker:

Kunio Agata (Japan)

Title:

Legionella control methods in various water systems in Japan

17:10-17:30

Speaker:

Hiromu Ishii (Toyohashi University of Thechnology, Japan)

Title:

Detection of Legionella by Photogate-type Optical Sensor

From general abstracts
17:30-17:40
(id067)

Speaker:

Sooji Lee (U.S. Centers for Disease Control and Prevention)

Title:

Legionnaires' disease associated with vacation rental properties

17:40-17:50
(id010)

Speaker:

Sebastian Crespi (Laboratory and Environmental Health Services. Biolinea Int. Spain)

Title:

A community outbreak of Legionnaires’ disease caused by outdoor hot tubs for private use in a hotel

Pathogenesis 3: (September 23, JST 9:00-10:05)

Legionella Genomics and Genetics

Chair:

Hiroki Nagai (Gifu University, Japan)
Elizabeth Hartland (Monash University, Australia)

9:00-9:25

Speaker:

Carmen Buchrieser (Institut Pasteur, France)

Title:

A Legionella pneumophila histone deacetylase: Genomics, evolution and function

9:25-9:50

Speaker:

Matthias Machner (National Institute of Child Health and Human Development, USA)

Title:

Legionella hijacks host cell Ras GTPases to rewire cellular signaling networks.

From general abstracts
(id055)
9:50-10:05

Speaker:

Anaisa B Moreno (Department of Medical Biochemistry and Microbiology, Science for Life Laboratories, Uppsala University)

Title:

Host-specific determinants of L. pneumophila virulence passaged in single hosts and in alternation

Pathogenesis 4: (September 23, JST 10:15-12:00)

New frontiers of Legionella Biology

Chair:

Carmen Buchrieser (Institut Pasteur, France)
Tomoko Kubori (Gifu University, Japan)

10:15-10:40

Speaker:

Sagar Bhogaraju (European Molecular Biology Laboratory)

Title:

Mechanistic insights into two effector-metaeffector pairs of Legionella

10:40-11:05

Speaker:

Zhao-Qing Luo (Purdue University, USA)

Title:

The ADP-ribosylation arsenals of Legionella pneumophila

From general abstracts
11:05-11:20
(id048)

Speaker:

Margaux Pillon (CIRI, Centre International de Recherche en Infectiologie, (Team: Legionella pathogenesis), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.)

Title:

The LegK2/VipA effector pair controls host actin polymerization at the Legionella containing vacuole

11:20-11:35
(id064)

Speaker:

Gunnar N. Schroeder (Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast)

Title:

Characterisation of LtpD-family T4SS effectors reveals functional diversification

11:35-11:50
(id097)

Speaker:

Ramona Neunuebel (Department of Biological Sciences, University of Delaware)

Title:

The Legionella effector protein Lpg2411 promotes autophagy during late infection

Lunch Seminar 3 (KYORIN Pharmaceutical Co., Ltd. )
(September 23, JST 12:10-13:00)

Chair:

Yoshikazu Ishii (Department of Microbiology and Infectious Diseases, Toho University, Japan)

Speaker:

Tetsuji Aoyagi (Department of Microbiology and Infectious Diseases, Toho University, Japan)

Title:

Infectious Diseases following Natural Disasters: Impact of Legionellosis on Survivors

Sponsored Symposium 4 (Pall Corporation)
(September 23, JST 13:10-14:00)

Chair:

Nicholas Ashbolt (Southern Cross University, Australia)

Speaker:

Fumiaki Kura (Department of Bacteriology I, National Institute of Infectious Diseases, Japan)

Title:

Healthcare-associated Legionella infection and countermeasures learned from case studies

Keynote Lecture 4 (September 23, JST 14:10-14:40)

Chair:

Hiroki Nagai (Gifu University, Japan)

Speaker:

Craig Roy (Yale University School of Medicine, USA)

Title:

Manipulation of Host Autophagy by Legionella

Epidemiology and Prevention 4: (September 23, JST 14:50-16:20)

The new European Drinking Water Directive: how different countries have transpose it

Chair:

Maria Luisa Ricci (Istituto Superiore di Sanità, Italy)

14:50-15:10

Speaker:

Maria Luisa Ricci (Istituto Superiore di Sanità, Italy)

Title:

The New European Directive (DWD) 2020/2184: how has Italy implemented it for Legionella control?

15:10-15:30

Speaker:

Martin Exner (Germany)

Title:

Risk regulatory experiences for prevention and control of Legionella in water systems in Germany.

15:30-15:50

Speaker:

Philippe Hartemann (France)

Title:

Early consideration of the legionellosis risk in France: reasons, prevention measures and results.

15:50-16:10

Speaker:

Paul van der Wielen (Netherlands)

Title:

Changing Dutch Legionella legislation for drinking water: from Legionella spp to L. pneumophila?

Topics of Legionella
(September 23, JST 16:30-17:30)

Chair:

Vladimír Drašar (Czech Republic)
Ryosuke Nakai (National Institute of Advanced Industrial Science and Technology, Japan)

16:30-16:50

Speaker:

Laura Tingley (NCTC)

Title:

Species of the bacterial family Legionellaceae: a review

16:50-17:10

Speaker:

Sho Shimada (Toho University, Japan)

Title:

Legionella spp. in the extreme environment of Antarctica

17:10-17:30

Speaker:

Vladimír Drašar (Czech Republic)

Title:

Routine isolation of novel Legionella species from different habitats

Introduction of 11th International Conference on Legionella
(September 23, JST 17:40-18:00)

Legionella, Biofilm and Functional Water Joint Symposium
(September 24, JST 9:00-12:00)

Chair:

Nobuhiko Nomura (University of Tsukuba, Japan)
Maria Luisa Ricci (Istituto Superiore di Sanità, Italy)
Kunimoto Hotta (Functional Water Foundation)

9:00-9:30

Speaker1 from Biofilm:

Nobuhiko Nomura (University of Tsukuba, Japan)

Title:

Biofilms and membrane vesicles

9:30-10:00

Speaker2 from Biofilm:

Shinya Sugimoto (The Jikei University School of Medicine, Japan)

Title:

Development of a new optical clearing method to visualize biofilms

10:00-10:30

Speaker1 from Legionella:

Hiroyuki Yamaguchi (Hokkaido University, Japan)

Title:

Interactions between protozoa and bacteria: a hint for understanding bacterial dynamics in natural environments

10:30-11:00

Speaker2 from Legionella:

Frederik Hammes (Drinking Water Microbiology Eawag, Switzerland)

Title:

Legionella in complex biofilms: collaborators and antagonists within the building plumbing microbiome

11:00-11:30

Speaker1 from the Japanese Society for Functional Water

Kunimoto Hotta (Functional Water Foundation)

Title:

Electrolytically-generated Hypochlorous Acid Water: Scientific Basis and Application of Anti-microbial Activities.

11:30-12:00

Speaker2 from the Japanese Society for Functional Water

Ayumu Umemoto (TOTO Ltd.)

Title:

Suppression of Biofilm on Residential Equipments with Water Supply by Tap Water Derived Electrolyzed Functional Water